Unique Brain Areas Associated with Abstinence Control Are Damaged in Multiply Detoxified Alcoholics
نویسندگان
چکیده
منابع مشابه
Unique Brain Areas Associated with Abstinence Control Are Damaged in Multiply Detoxified Alcoholics
BACKGROUND The ability to abstain from drinking, despite incentives to imbibe, is essential to recovery from alcoholism. METHODS We used an incentive conflict task to investigate ability to abstain from responding during presentations of incentive cues. Both alcoholic (n = 23) and healthy subjects (n = 22) were required to withhold responding during the simultaneous presentation of two visual...
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Detoxified male and female alcoholics (aged 20-49 years) and age-matched controls performed a series of 15-sec target-tapping tasks in which they alternatively marked two target strips with a felt marker as rapidly and as accurately as possible. Consistent with "Fitts' Law" (Fitts PM: J Exp Psych 47:381-391, 1954), a highly linear relationship between movement time and task difficulty was obser...
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A 16-week, randomized study was performed to test the efficacy of two selective serotonin reuptake inhibitors (SSRIs) fluvoxamine and citalopram, in decreasing relapse and craving in alcoholics, and to investigate possible differences in their clinical profile. After detoxification, each of the 81 patients (55 males and 26 females) was randomly assigned to one of three groups: 23 subjects did n...
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Objective: Cholinergic neurons in the nucleus accumbens (NAc) express δ and μ receptors that are thought to inhibit neural activity (Britt & McGehee, 2008). δ and μ receptors are divided into δ1 and δ2 receptors and μ1 and μ2 receptors, respectively. Therefore, we analysed the roles of δ and μ receptor subtypes in regulating accumbal acetylcholine (ACh) efflux using in vivo microdialysis. Metho...
متن کاملAuditory assessment of alcoholics in abstinence.
UNLABELLED Alcoholism is considered the most relevant addiction in the international arena and few investigations have examined the association between sensorineural hearing loss and alcohol abuse, with conflicting results. AIM To analyze the effects of alcohol abuse on the auditory system of alcoholics in abstinence taking into account the duration of alcohol abuse and associated noise expos...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2011
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2011.04.006